Liver, Pancreas, Biliary Cancer Clinical Trials

The goal of our clinical research program at Virginia Mason Franciscan Health is to provide you with a research option at every step of their disease, from initial diagnosis to long-term follow-up of liver disease.

The Center for Digestive Health research program offers clinical trials in various chronic liver diseases in conjunction with Benaroya Research Institute and the Liver Center of Excellence.

Learn more about our current liver disease trials for chronic liver conditions and liver cancer.

A Study to Evaluate the Efficacy and Safety of Pemigatinib Versus Chemotherapy in Unresectable or Metastatic Cholangiocarcinoma (FIGHT-302).

A Phase III Open-Label, Multi-Centre, Randomized Study Comparing NUC-1031 plus Cisplatin to Gemcitabine plus Cisplatin in Patients with Previously Untreated Locally Advanced or Metastatic Biliary Tract Cancer.

Safety and Efficacy of Pembrolizumab (MK-3475) Versus Placebo as Adjuvant Therapy in Participants with Hepatocellular Carcinoma (HCC) and Complete Radiological Response After Surgical Resection or Local Ablation (MK-3475-937 / KEY NOTE-937).

A Phase 2, Multicenter, Clinical Study to Evaluate the Safety and Efficacy of MK-1308A (Coformulated MK-1308/MK-3475) in Combination with Lenvatinib (E7080/MK-7902) in First-line Therapy of Participants with Advanced Hepatocellular Carcinoma.

A Phase 2, Randomized, Double-Blind, Double-Dummy, Placebo-Controlled Study Evaluating the Safety and Efficacy of Semaglutide, and the Fixed-Dose Combination of Cilofexor and Firsocostat, Alone and in Combination, in Subjects with Compensated Cirrhosis (F4) due to Nonalcoholic Steatohepatitis (NASH).

VM BRITE: A Tissue Registry and Specimen Repository to Support Future Research Projects

Stent vs. Indomethacin for Preventing Post-ERCP Pancreatitis: The SVI Trial

SHARP Trial: SpHincterotomy for Acute Recurrent Pancreatitis Trial

Diabetes Related to Acute pancreatitis and its Mechanisms (DREAM)

Alternating neoadjuvant Gemcitabine-Nab-Paclitaxel and nal-IRI with 5-Fluorouracil and folinic acid (Leucovorin) regimens in resectable and borderline resectable pancreatic cancer, A Pilot Study

Gemcitabine and Nab-Paclitaxel in Pancreatic Adenocarcinoma with Positive Peritoneal Cytology as a Sole Metastatic Site

Pivotal, randomized, open-label study of Tumor Treating Fields (TTFields, 150kHz) concomitant with gemcitabine and nab-paclitaxel for front-line treatment of locally-advanced pancreatic adenocarcinoma

Distal pancreatectomy, minimally invasive or open, for malignancy (DIPLOMA): a randomized controlled, multicenter, non-inferiority trial.

A Phase 3, Randomized, Double-Blind Study of Pamrevlumab or Placebo in combination with Gemcitabine Plus Nab-paclitaxel as Neoadjuvant Treatment in Patients with Locally Advanced, Unresectable Pancreatic Cancer

PRECISION PROMISESM PLATFORM TRIAL FOR METASTATIC PANCREATIC CANCER

A Phase 1a/b Dose-Escalation Study Followed by Expansion Cohorts of NGM120, a GFRAL Antagonist Monoclonal Antibody Blocking GDF15 Signaling, in Subjects With Advanced Solid Tumors and Pancreatic Cancer Using Combination Therapy

A Phase I/II Study of MCLA-128, a full length IgG1 Bispecific Antibody Targeting HER2 and HER3, in Patients with Solid Tumors

A Study to Evaluate the Safety, Tolerability, and Activity of TAK-931 in Participants With Metastatic Pancreatic Cancer, Metastatic Colorectal Cancer, and Other Advanced Solid Tumors

Alternative Neoadjuvant Chemotherapy in Resectable and Borderline Resectable Pancreatic Cancer

To learn about clinical trials in pancreatic cancer across the country, view the PanCAN Clinical Trials.

Currently enrolling clinical research studies related to endoscopy:

Stent vs. Indomethacin for Preventing Post-ERCP Pancreatitis: The SVI Trial

SHARP Trial: SpHincterotomy for Acute Recurrent Pancreatitis

To talk with a clinical research coordinator about non-cancer clinical research trials, call the Center for Digestive Health hotline at 206-341-1295.

To talk with a clinical research coordinator about clinical research trials related to liver, pancreatic, or biliary cancer, call the Cancer Clinical Research Unit Research hotline at 206-287-6270.