Mariko Harper, MD

Personal Information

Mariko Harper, MD, FACC is a board-certified cardiologist who specializes in all aspects of adult cardiology including: coronary artery disease, hyperlipidemia, valvular heart disease, arrhythmias, genetic/infiltrative cardiomyopathy, hypertrophic cardiomyopathy (HCM) and heart failure. She has a special expertise in advanced heart failure and advanced cardiac imaging with additional training and board certifications in both echocardiography and nuclear cardiology.

Dr. Harper serves as the Medical Director of The Hypertrophic Cardiomyopathy Center at Virginia Mason Franciscan Health. Under her direction, she has created a regional center providing an individualized approach to the diagnosis, genetic testing, advanced cardiac imaging and medical/surgical management of patients with HCM. Each patient is reviewed by a multidisciplinary team of physicians and treatment plans are designed with patient input, using a shared decision making model. The HCM Center offers comprehensive HCM treatments including: medical therapy, defibrillator implantation, alcohol septal ablation and surgical septal myectomy. The HCM Center is also one of the first centers in the PNW to offer the recently FDA-approved novel HCM medication mavacamten (Camzyos®) through a comprehensive drug safety program. She also serves as a principal investigator for ongoing HCM clinical trials.

Dr. Harper has authored and published multiple peer reviewed articles and book chapters in a wide range of topics in cardiology. She has been an invited speaker at both national and regional meetings on topics including hypertrophic cardiomyopathy, hyperlipidemia, and preventive cardiology. Following her passion for patient education and cardiovascular disease prevention, she is also one of the course directors for the "Food Is Medicine" continuing medical education lecture series at Virginia Mason Franciscan Health. Dr. Harper believes in patient-centered and patient-driven care. She emphasizes the importance of shared clinical decision making, with open dialogue between the patient and the entirety of the patient's multidisciplinary care team. 

Dr. Harper has been recognized as a Seattle Met Top Doctor in 2021 and 2022.

In her free time, she enjoys reading, gardening, running and spending time with her family.